Welcome to the Shiroguchi Lab ! - A Quantitative Omics Lab, Single Cell & Single Molecule Level -
At the end of summer 2012, I moved to Yokohama from Boston, and started research at the RCAI (currently, RIKEN Center for Integrative Medical Sciences (IMS)). Now, I am at the RIKEN Quantitative Biology Center (QBiC, Osaka). I have been working in the fields of biophysics and genomics, mainly developing techniques to "see" the unknown. I would like to leverage my experience and skills to continue developing new techniques in order to understand biological systems and to contribute to discoveries in medical science and disease research. In particular, I am interested in seeing shifts in distributions, e.g. of cell states, by accurate system-wide measurements with single molecule and/or single cell resolution. This is important since heterogeneity in cell populations may be one of the key features in biological systems. For example, at the beginning of a disease, homeostasis may start to break down at the single cell level. We are working on some projects that go along this direction. We also are interested in the conbination of imaging technique and gene expression analyses.
- Book chapter Paper accepted Syposium participation Japanese-American Frontiers of Science Symposium (JAFoS) Talk Symposium, Annual Meeting of the Biophysical Society Talk International Conference on Single Cell Research 2016 Japanese articles "デジタルRNAシークエンシング ゲノムワイドな１分子定量法" "次世代シークエンサーを用いたDNA, RNAの網羅的デジタル計測" Patent Filed