Welcome to the Shiroguchi Lab !        - A Quantitative Omics Lab, Single Cell & Single Molecule Level -

    At the end of summer 2012, I moved to Yokohama from Boston, and started my lab at the RCAI (currently, RIKEN Center for Integrative Medical Sciences (IMS)). Now, I am at the RIKEN Quantitative Biology Center (QBiC, Osaka).
    I have been working in the fields of biophysics and genomics, mainly developing techniques to "see" the unknown. I would like to leverage my experience and skills to continue developing new techniques in order to understand biological systems and to contribute to discoveries in medical science and disease research. In particular, I am interested in seeing shifts in distributions, e.g. of cell states, by accurate system-wide measurements with single molecule and/or single cell resolution. This is important since heterogeneity in cell populations may be one of the key features in biological systems. For example, at the beginning of a disease, homeostasis may start to break down at the single cell level. We are working on some projects that go along this direction. We also are interested in the conbination of imaging technique and gene expression analyses.

Latest News

    Patent     Filed

    Talk     QBiC Symposium 2016

    Talk     新学術領域「少数性生物学」

    Talk     Immmunology Seminar, Okayama Univ.

    Talk     QBiC Seminar

    Grant       PRESTO (Sakigake) accepted

    Talk      Symposium "Biological events operated by small number of biomolecules"
                The 53rd Annual Meeting of the Biophysical Society of Japan 第53回日本生物物理学会年会

    Talk     "Digital counting of mRNA molecules genome-wide by molecular barcoding"
                Okinawa Institute of Science and Technology (OIST) 沖縄科学技術大学院大学

    Talk     "Single cell analysis using the next generation sequencer"
                京都大学ウイルス研究所 生物情報解析研修会