Welcome to the Shiroguchi Lab !        - A Quantitative Omics Lab, Single Cell & Single Molecule Level -

        I have been working in the fields of biophysics and genomics, mainly developing techniques to "see" the unknown. I would like to leverage my experience and skills to continue developing new techniques in order to understand biological systems and to contribute to discoveries in medical science and disease research. In particular, I am interested in seeing shifts in distributions, e.g. of cell states, by accurate system-wide measurements with single molecule and/or single cell resolution. This is important since heterogeneity in cell populations may be one of the key features in biological systems. For example, at the beginning of a disease, homeostasis may start to break down at the single cell level. We are working on some projects that go along this direction. We also are interested in the conbination of imaging technique and gene expression analyses.

Latest News

    Postdoc position available

    Talk in MELIS-UPF and RIKEN BDR Symposium

    Paper published
    "Pigmentation level of human iPSC-derived retinal pigment epithelium cell does not indicate a specific gene expression profile"
    Nakai-Futatsugi, et al.    eLife.

    Review paper accepted

    Talk in RIKEN BDR Symposium 2024

    生物物理 64(1) 35-37 (2024)

    Paper published
    "Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch"
    Takahashi, et al.    Cell Reports.    プレスリリース

    Paper published
    "High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ"
    Jin, et al.    Nature Protocols.    プレスリリース

    Talk in 16th Inernational Symposium on Nanomedicine

    Lecture in School of Advanced Science and Enginnering, Waseda University

    Tomoaki Okaniwa received the Student Presentation Award in the annual meeting of Biophysical Society Japan 2023.

    Talk in The 96th Annual Meeting of the Japanese Biochemical Society (第96回日本生化学会大会) 3S02e

    Paper published
    "CD45 Alleviates Airway Inflammation and Lung Fibrosis by Limiting Expansion and Activation of ILC2s"
    Cui, et al.    Proc. Natl. Acad. Sci. USA.    プレスリリース
               featured in Tii生命科学,   医療NEWS

    Paper published
    "Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics"
    Fujimura, et al.    Stem Cells.    プレスリリース

    光アライアンス (日本工業出版) Vol.34 No.8 p1-3 (2023)

    Talk in 3rd Nobel Turing Challenge Initiative Workshop

    Jianshi (Frank) Jin, a former postdoc, became a PI in the Institute of Zoology, Chinese Academy of Sciences.