Welcome to the Shiroguchi Lab ! - A Quantitative Omics Lab, Single Cell & Single Molecule Level -
I have been working in the fields of biophysics and genomics, mainly developing techniques to "see" the unknown. I would like to leverage my experience and skills to continue developing new techniques in order to understand biological systems and to contribute to discoveries in medical science and disease research. In particular, I am interested in seeing shifts in distributions, e.g. of cell states, by accurate system-wide measurements with single molecule and/or single cell resolution. This is important since heterogeneity in cell populations may be one of the key features in biological systems. For example, at the beginning of a disease, homeostasis may start to break down at the single cell level. We are working on some projects that go along this direction. We also are interested in the conbination of imaging technique and gene expression analyses.
Latest News
- Postdoc position available Paper published "RelB and C/EBPα critically regulate the development of Peyer’s patch mononuclear phagocytes" Kanaya, et al. Mucosal Immunology. Review paper published "Long journey of 16S rRNA-amplicon sequencing toward cell-based functional bacterial microbiota characterization" Jin, et al. iMetaOmics. Talk in NCBS-RIKEN BDR Joint Meeting Talk in Symposium 14 "Data Science, Machine Learning, and Analytical Frameworks for Understanding the Heterogeneity of Cellular and Multicellular Systems", IUPAB 2024 Talk in MELIS-UPF and RIKEN BDR Symposium Paper published "Pigmentation level of human iPSC-derived retinal pigment epithelium cell does not indicate a specific gene expression profile" Nakai-Futatsugi, et al. eLife. Review paper accepted Talk in RIKEN BDR Symposium 2024 記事 "個々の細胞の画像から遺伝子発現状態を推定する" 生物物理 64(1) 35-37 (2024) Paper published "Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch" Takahashi, et al. Cell Reports. プレスリリース Paper published "High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ" Jin, et al. Nature Protocols. プレスリリース Talk in 16th Inernational Symposium on Nanomedicine Lecture in School of Advanced Science and Enginnering, Waseda University Congratulations! Tomoaki Okaniwa received the Student Presentation Award in the annual meeting of Biophysical Society Japan 2023. Talk in The 96th Annual Meeting of the Japanese Biochemical Society (第96回日本生化学会大会) 3S02e Paper published "CD45 Alleviates Airway Inflammation and Lung Fibrosis by Limiting Expansion and Activation of ILC2s" Cui, et al. Proc. Natl. Acad. Sci. USA. プレスリリース featured in Tii生命科学, 医療NEWS Paper published "Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics" Fujimura, et al. Stem Cells. プレスリリース 記事 "細胞の明視野画像から細胞種や状態を読み取る基盤技術" 光アライアンス (日本工業出版) Vol.34 No.8 p1-3 (2023) Talk in 3rd Nobel Turing Challenge Initiative Workshop Congratulations! Jianshi (Frank) Jin, a former postdoc, became a PI in the Institute of Zoology, Chinese Academy of Sciences.