Welcome to the Shiroguchi Lab !        - A Quantitative Omics Lab, Single Cell & Single Molecule Level -


        I have been working in the fields of biophysics and genomics, mainly developing techniques to "see" the unknown. I would like to leverage my experience and skills to continue developing new techniques in order to understand biological systems and to contribute to discoveries in medical science and disease research. In particular, I am interested in seeing shifts in distributions, e.g. of cell states, by accurate system-wide measurements with single molecule and/or single cell resolution. This is important since heterogeneity in cell populations may be one of the key features in biological systems. For example, at the beginning of a disease, homeostasis may start to break down at the single cell level. We are working on some projects that go along this direction. We also are interested in the conbination of imaging technique and gene expression analyses.




Latest News


    Talk in Research Society for Cancer 3-D Cluture

    Patent application filed

    Talks in National University of Singapore and A*STAR GIS

    Talk in 3rd Spatial Biology Congress: Asia

    Patent application filed

    Paper published
    "Finding differentially expressed genes between cell fates predicted by image-based deep learning"
    Okaniwa, et al.    Biophysics and Physicobiology

    Talk in Proteome meeting (JPrOS2025 (23rd JHUPO))

    Patent application filed

    Paper published
    "KLF2 expression in IgG plasma cells at their induction site regulates the migration program"
    Ise, et al.    J. Exp. Med.

    Paper published
    "RelB and C/EBPα critically regulate the development of Peyer’s patch mononuclear phagocytes"
    Kanaya, et al.    Mucosal Immunology.

    Review paper published
    "Long journey of 16S rRNA-amplicon sequencing toward cell-based functional bacterial microbiota characterization"
    Jin, et al.    iMetaOmics.